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1. Lake IR, Jones NR, Agnew M, Goodess CM, Giorgi F, Hamaoui-Laguel L, et al. Climate change and future pollen allergy in Europe. Environ Health Perspect. 2017; 125(3): 385–391.2. Горячкина ЛА, Дробик ОС, Насунова АЮ. Поллинозы: современный взгляд на проблему. Вестник семейной медицины. 2012; 1: 10–6. [Goryachkina LA, Drobik OS, Nasunova AYU. Pollinozy: sovremennyj vzglyad na problemu. Vestnik semejnoj mediciny. 2012; 1: 10–6. (InRuss.)]3. Pointner L, Bethanis A, Thaler M, Traidl-Hoffmann C, Gilles S, Ferreira F, Aglas L. Initiating pollen sensitization — complex source, complex mechanisms. Clin Transl Allergy. 2020; 10: 36.4. Емелина ЮН, Воронцова ОА, Бельтюков ЕК. Анализ аэропалинологического спектра в г. Екатеринбурге. Аллергология и иммунология в педиатрии. 2021; 4: 42–44. [Emelina UN, Voroncova OA, Bel’tyukov EK. Analiz aeropalinologicheskogo spektra v g. Ekaterinburge. Allergologia i immunologia v pediatrii. 2021; 4: 42–44. (InRuss.)]5. Балаболкин ИИ. Поллиноз у детей и подростков: современные аспекты патогенеза и тенденции в терапии. Аллергология и иммунология в педиатрии. 2020; 3 (62): 6–14. [Balabolkin II. Pollinoz u detej i podrostkov: sovremennye aspekty patogeneza i tendencii v terapii. Allergologia i immunologia v pediatrii. 2020; 3 (62): 6–14. (InRuss.)]6. Treudler R. Simon JC. Pollen-related food allergy: an update. Allergol J Intern. 2017; 26: 273–282.7. Descotes J, Choquet-Kastylevsky G. Gell and Coombs’s classification: is it still valid? Toxicology. 2001; 158 (1–2): 43–49.8. Kumar S, Jeong Y, Ashraf MU, Bae YS. Dendritic cell-mediated Th2 immunity and immune disorders. Int J Mol Sci. 2019; 20 (9): 2159.9. Blumchen K, Kallinich T, Hamelmann E. Interleukin-5: a novel target for asthma therapy. Expert Opin Biol Ther. 2001; 1 (3): 433–453.10. Seyfizadeh N, Seyfizadeh N, Gharibi T, Babaloo Z. Interleukin-13 as an important cytokine: a review on its roles in some human diseases. Acta Microbiol Immunol Hung. 2015; 62 (4): 341–378.11. Soyer OU, Akdis M, Ring J, Behrendt H, Crameri R, Lauener R, et al. Mechanisms of peripheral tolerance to allergens. Allergy. 2013; 68 (2): 161–170.12. Liu AH. Revisiting the hygiene hypothesis for allergy and asthma. J Allergy Clin Immunol. 2015; 136 (4): 860–865.13. Potaczek DP, Harb H, Michel S, Alhamwe BA, Renz H, Tost J. Epigenetics and allergy: from basic mechanisms to clinical applications. Epigenomics. 2017; 9 (4): 539–571.14. Mattila P, Joenvaara S, Renkonen J, Toppila-Salmi S, Renkonen R. Allergy as an epithelial barrier disease. Clin Transl Allergy. 2011; 1 (1): 5.15. Gilles-Stein S, Beck I, Chaker A, Bas M, McIntyre M, Cifuentes L, et al. Pollen derived low molecular compounds enhance the human

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To grass pollen allergens in mice. Allergy. 2020; 75 (4): 882–891.41. Wimmer M, Alessandrini F, Gilles S, Frank U, Oeder S, Hauser M, et al. Pollen-derived adenosine is a necessary cofactor for ragweed allergy. Allergy. 2015; 70 (8): 944–954.42. Wolf M, Twaroch TE, Huber S, Reithofer M, Steiner M, Aglas L, et al. Amb a 1 isoforms: unequal siblings with distinct immunological features. Allergy. 2017; 72 (12): 1874–1882.43. Eisenbarth SC, Zhadkevich A, Ranney P, Herrick CA, Bottomly K. IL-4-dependent Th2 collateral priming to inhaled antigens independent of toll-like receptor 4 and myeloid differentiation factor 88. J Immunol. 2004; 172 (7): 4527–4534.44. Soh WT, Aglas L, Mueller GA, Gilles S, Weiss R, Scheiblhofer S, et al. Multiple roles of Bet v 1 ligands in allergen stabilization and modulation of endosomal protease activity. Allergy. 2019; 74 (12): 2382–2393.45. Gilles S, Behrendt H, Ring J, Traidl-Hoffmann C. The pollen enigma: modulation of the allergic immune response by non-allergenic, pollenderived compounds. Curr Pharm Des. 2012; 18 (16): 2314–2319.46. Chruszcz M, Chew FT, Hoffmann-Sommergruber K, Hurlburt BK, Mueller GA, Pomés A et al. Allergens and their associated small molecule ligands-their dual role in sensitization. Allergy. 2021; 76 (8): 2367–2382.47. Gisler A. Allergies in Urban Areas on the Rise: The Combined Effect of Air Pollution and Pollen. Int J Public Health. 2021; 66: 1604022.48. Bublin M, Eiwegger T, Breiteneder H. Do lipids influence the allergic sensitization process? J Allergy Clin Immunol. 2014; 134 (3): 521–529.49. Agea E, Russano A, Bistoni O, Mannucci R, Nicoletti I, Corazzi L, et al. Human CD1-restricted T cell recognition of lipids from pollens. J Exp Med. 2005; 202 (2): 295–308.50. Gilles S, Mariani V, Bryce M, Mueller MJ, Ring J, Behrendt H, et al. Pollen allergens do not come alone: pollen associated lipid mediators (PALMS) shift the human immune systems towards a T(H)2-dominated response. Allergy Asthma Clin Immunol. 2009; 5 (1): 3.51. Gunawan H, Takai T, Kamijo S, Wang XL, Ikeda S, Okumura K, et al. Characterization of proteases, proteins, and eicosanoid-like substances in soluble extracts from allergenic pollen grains. Int Arch Allergy Immunol. 2008; 147 (4): 276–288.52. Oeder S, Alessandrini F, Wirz OF, Braun A, Wimmer M, Frank U, et al. Pollen-derived nonallergenic substances enhance Th2-induced IgE production in B cells. Allergy. 2015; 70 (11): 1450–1460.53. Gilles S, Fekete A, Zhang X, Beck I, Blume C, Ring J, et al. Pollen metabolome analysis reveals adenosine as a major regulator of

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Allergen specific immune response in vivo. Clin Exp Allergy. 2016; 46 (10): 1355–1365.16. McKenna OE, Posselt G, Briza P, Lackner P, Schmitt AO, Gadermaier G, et al. Multi-approach analysis for the identification of proteases within birch pollen. Int J Mol Sci. 2017; 18 (7): 1433.17. Mabalirajan U. Possible involvement of protease-mediated neutrophil recruitment and epithelial barrier disruption in ragweed pollen sensitization. Am J Respir Cell Mol Biol. 2017; 56 (2): 271–272.18. Van Cleemput J, Poelaert KCK, Laval K, Impens F, Van den Broeck W, Gevaert K, et al. Pollens destroy respiratory epithelial cell anchors and drive alphaherpesvirus infection. Sci Rep. 2019; 9 (1): 4787.19. Lopez-Rodriguez JC, Solis-Fernandez G, Barderas R, Villalba M, Batanero E. Effects of Ole e 1 on Human Bronchial Epithelial Cells Cultured at the Air-Liquid Interface. J Investig Allergol Clin Immunol. 2018; 28 (3): 186–189.20. Kumamoto J, Tsutsumi M, Goto M, Nagayama M, Denda M. Japanese Cedar (Cryptomeria japonica) pollen allergen induces elevation of intracellular calcium in human keratinocytes and impairs epidermal barrier function of human skin ex vivo. Arch Dermatol Res. 2016; 308 (1): 549–544.21. Hosoki K, Brasier AR, Kurosky A, Boldogh I, Sur S. Reply: protease plays a role in ragweed pollen-induced neutrophil recruitment and epithelial barrier disruption. Am J Respir Cell Mol Biol. 2017; 56 (2): 272–273.22. Zhu DD, Zhu XW, Jiang XD, Dong Z. Thymic stromal lymphopoietin expression is increased in nasal epithelial cells of patients with mugwort pollen sensitive-seasonal allergic rhinitis. Chin Med J (Engl). 2009; 122 (19): 2303–2307.23. Deng R, Chen X, Zhang Y, Bian F, Gao N, Hu J, et al. Short ragweed pollen promotes M2 macrophage polarization via TSLP/TSLPR/OX40L signaling in allergic inflammation. Mucosal Immunol. 2019; 12 (5): 1141–1149.24. Hosoki K, Redding D, Itazawa T, Chakraborty A, Tapryal N, Qian S, et al. Innate mechanism of pollen- and cat dander-induced oxidative stress and DNA damage in the airways. J Allergy Clin Immunol. 2017; 140 (5): 1436–9. e5.25. Li J, Zhang L, Chen X, Chen D, Hua X, Bian F, et al. Pollen/TLR4 innate immunity signaling initiates IL-33/ST2/Th2 pathways in allergic inflammation. Sci Rep. 2016; 6: 36150.26. Akasaki S, Matsushita K, Kato Y, Fukuoka A, Iwasaki N, Nakahira M, et al. Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways. Int Immunol. 2016; 28 (2): 65–76.27. Mjosberg JM, Trifari S, Crellin NK, Peters CP, van Drunen CM, Piet B, et al. Human IL-25- and IL-33-responsive

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